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General treatment, such as changing living habits, is preferred, and medical or surgical treatment should not be considered in the absence of serious malignancy

Some GLP-1 agonists, like Zepbound, Wegovy, and Saxenda (liraglutide), are FDA approved for chronic weight management

Fibrosis stage is the strongest predictor of mortality in patients with NAFLD, and FDA guidance on treatments for NAFLD stresses the importance not only of liver fat reduction, but also of prevention of fibrosis and reduction of inflammation (28)

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